Pyridine Analogues As An Anticancer Agents

Name: Pyridine Analogues As An Anticancer Agents
Brand: LAP Lambert Academic Publishing
SKU: 9783659292729
Price: 163.37 RON
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Autor: Sunil Shingade, Mitali Naik

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Editura: LAP Lambert Academic Publishing

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A series of N-(3-cyano-4,6-diphenylpyridin-2-yl)heteroaryl-4-carboxamide derivatives were synthesize...

Informații despre carte

Autor

Sunil Shingade, Mitali Naik

Limbă

engleză

Legare

Carte - Carte broșată

Publicat

2017

Pagini

EAN

9783659292729

Enbook ID

18366625

Editura

LAP Lambert Academic Publishing

Greutate

143

Dimensiuni

150 x 220 x 5

Descriere completă

A series of N-(3-cyano-4,6-diphenylpyridin-2-yl)heteroaryl-4-carboxamide derivatives were synthesized using nitrogen containing heterocycles. The chemistry of the reactions employed in the synthesis of the target compounds along with biological properties is discussed in this research work. The synthesized compounds were satisfactorily characterized by IR, 1HNMR and 13CNMR spectroscopy. Five synthesized compounds (6a-e) were tested for in vitro anticancer activity against MCF-7 cell line. The in vitro activity was based upon MTT assay method. The anticancer activity results showed that, among the tested compounds, compound 6d was found to be most active with IC50 value 10 µg whereas compound 6e was moderately active with IC50 value 30 µg against the MCF-7 cell line.

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Pyridine Analogues As An Anticancer Agents

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