Drug Targeting

Name: Drug Targeting
Brand: Humana Press Inc.
SKU: 9781489941718
Price: 550.27 RON
Availability: InStock

Strategies, Principles, and Applications

Autor: G. E. Francis

Limbă:

Legare: Carte broșată

Editura: Humana Press Inc.

Disponibilitate: În depozitul extern

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Advances in understanding the molecular mechanisms of disease together with the advent of recombinan...

Informații despre carte

Autor

G. E. Francis

Limbă

engleză

Legare

Carte - Carte broșată

Publicat

2013

Pagini

318

EAN

9781489941718

ISBN

1489941711

Enbook ID

05182161

Editura

Humana Press Inc.

Greutate

487

Dimensiuni

152 x 229 x 19

Descriere completă

Advances in understanding the molecular mechanisms of disease together with the advent of recombinant DNA and other technologies have opened opportunities for a vast array of novel therapeutic biopharmaceuticals and diagnostic agents. However, even natural biomolecules present a myriad of problems that limit their potential as pharmaceutical agents. Rapid degra- tion and elimination, immunological reactions, and toxicity are often asso- ated with new biopharmaceuticals, much as with conventional agents. Targeted delivery systems have the potential to increase the efficacy of existing diagnostic and therapeutic agents and also create an opportunity for the use of new pharmaceuticals, substances that themselves can be harmful to normal tissues. Both passive and active targeting have been exploited. Most active targ- ing strategies have focused on antibody conjugates since preparation of highly specific monoclonal antibodies is well established. However, a new wave of c- jugates exploiting other ligands is underway. Access to the target tissue remains an obstacle and is an area where passive targeting can be useful. In Drug Targeting: Strategies, Principles, and Applications we have tried to compile a state-of-the-art volume on current targeting approaches. The first section focuses on certain key strategies applied to date, and how to build the antibody ligand constructs. This is followed by a section on theoretical considerations for t- geting, focusing on approaches relevant to solid tumors. The last section deals with some experimental and clinical applications of targeted drug delivery systems.

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Drug Targeting

Strategies, Principles, and Applications

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