Vanadium in Biological Systems

Name: Vanadium in Biological Systems
Brand: Springer
SKU: 9789401074070
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Physiology and Biochemistry

Autor: N.D. Chasteen

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Editura: Springer

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Over the past several decades, vanadium has increasingly attracted the interest of biologists and ch...

Informații despre carte

Autor

N.D. Chasteen

Limbă

engleză

Legare

Carte - Carte broșată

Publicat

2011

Pagini

226

EAN

9789401074070

ISBN

9401074070

Enbook ID

02185038

Editura

Springer

Greutate

367

Dimensiuni

155 x 235 x 13

Descriere completă

Over the past several decades, vanadium has increasingly attracted the interest of biologists and chemists. The discovery by Henze in 1911 that certain marine ascidians accumulate the metal in their blood cells in unusually large quantities has done much to stimulate research on the role of vanadium in biology. In the intervening years, a large number of studies have been carried out to investigate the toxicity of vanadium in higher animals and to determine whether it is an essential trace element. That vanadium is a required element for a few selected organisms is now well established. Whether vanadium is essential for humans remains unclear although evidence increasingly suggests that it probably is. The discovery by Cantley in 1977 that vanadate is a potent inhibitor of ATPases lead to numerous studies of the inhibitory and stimulatory effects of vanadium on phosphate metabolizing enzymes. As a consequence vanadates are now routinely used as probes to investigate the mechanisms of such enzymes. Our understanding of vanadium in these systems has been further enhanced by the work of Tracy and Gresser which has shown striking parallels between the chemistry of vanadates and phosphates and their biological compounds. The observation by Shechter and Karlish, and Dubyak and Kleinzeller in 1980 that vanadate is an insulin mimetic agent has opened a new area of research dealing with the hormonal effects of vanadium. The first vanadium containing enzyme, a bromoperoxidase from the marine alga Ascophyllum nodosum, was isolated in 1984 by Viltner.

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Vanadium in Biological Systems

Physiology and Biochemistry

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