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Validation of Alternative Methods for Toxicity Testing

Name: Validation of Alternative Methods for Toxicity Testing
Brand: Springer International Publishing AG
SKU: 9783319338248
Price: 939.26 RON
Availability: InStock

Autor: Chantra Eskes, Maurice Whelan

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Legare: Copertă tare

Editura: Springer International Publishing AG

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939.26 lei

This book provides information on best practices and new thinking regarding the validation of altern...

Informații despre carte

Autor

Chantra Eskes, Maurice Whelan

Limbă

engleză

Legare

Carte - Copertă tare

Publicat

2016

Pagini

407

EAN

9783319338248

ISBN

3319338242

Enbook ID

02975445

Editura

Springer International Publishing AG

Greutate

7627

Dimensiuni

155 x 235 x 28

Descriere completă

This book provides information on best practices and new thinking regarding the validation of alternative methods for toxicity testing. It covers the validation of experimental and computational methods and integrated approaches to testing and assessment. Validation strategies are discussed for methods employing the latest technologies such as tissue-on-a-chip systems, stem cells and transcriptomics, and for methods derived from pathway-based concepts in toxicology.§§Validation of Alternative Methods for Toxicity Testing is divided into two sections, in the first, practical insights are given on the state-of-the-art and on approaches that have resulted in successfully validated and accepted alternative methods. The second section focuses on the evolution of validation principles and practice that are necessary to ensure fit-for-purpose validation that has the greatest impact on international regulatory acceptance of alternative methods. In this context validation needs to keep pace with the considerable scientific advancements being made in toxicology, the availability of sophisticated tools and techniques that can be applied in a variety of ways, and the increasing societal and regulatory demands for better safety assessment.§§This book will be a useful resource for scientists in the field of toxicology, both from industry and academia, developing new test methods, strategies or techniques, as well as Governmental and regulatory authorities interested in understanding the principles and practicalities of validation of alternative methods for toxicity testing.§§

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