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Treatment-Resistant Depression

Name: Treatment-Resistant Depression
Brand: John Wiley and Sons Ltd
SKU: 9781119952909
Price: 260.26 RON
Availability: InStock

Autor: Siegfried Kasper

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Legare: Carte broșată

Editura: John Wiley and Sons Ltd

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260.26 lei

Successful management of patients with treatment-resistant depression is going to require a thorough...

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Autor

Siegfried Kasper

Limbă

engleză

Legare

Carte - Carte broșată

Publicat

2013

Pagini

228

EAN

9781119952909

ISBN

1119952905

Enbook ID

01298906

Editura

John Wiley and Sons Ltd

Greutate

218

Dimensiuni

200 x 128 x 11

Descriere completă

Successful management of patients with treatment-resistant depression is going to require a thorough understanding of the biological basis for both the depression and its failure to respond to standard treatments. This book clearly and succinctly summarizes the latest scientific research and its applications in clinical practice.§A first step is a clear definition of what constitutes treatment-resistant depression so that clinical trials and other studies are using common criteria, enabling comparison and meta-analysis of their outcomes. The opening chapter reviews definitions and predictors of originating from different fields and discusses their usefulness in clinical practice and clinical research. The next chapter proposes a new definition, adapting terminology from medicine.§Biological classification requires identification of genetic risk factors: with gene variants accounting for 50% of the variance in the clinical outcomes of antidepressant treatments this is clearly a fruitful area of research. Chapter 3 describes several genes already associated with treatment-resistant depression and, while further work is needed to translate findings into clinical recommendations, predicts that genetic prediction of TRD could became a widespread clinical reality within a few years.§Most patients with TRD will be treated pharmacologically and three chapters review the latest evidence for pharmacological best practice, including switching strategies for antidepressants, the role of antipsychotics and augmentation strategies to complement lithium.§There are two major alternatives to pharmacotherapy: neuromodulation and psychotherapy. The brain intervention chapter summarizes clinical research and experience with electroconvulsive therapy, transcranial magnetic stimulation, vagus nerve stimulation, deep brain stimulation and magnetic seizure therapy. The final chapter reviews the literature pertaining to the effectiveness of various forms of psychotherapy in patients who have not responded to antidepressant pharmacotherapy, revealing that patients who have not responded to one or two trials of antidepressant medication have a 30%-50% chance of responding to a focused psychotherapy. It proposes indications for psychotherapy in TRD and summarizes general therapeutic principles.

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Treatment-Resistant Depression

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