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This volume focuses on modern computational and statistical tools for translational gene expression and regulation research to improve prognosis, diagnostics, prediction of severity, and therapies for human diseases. It introduces some of state of the art technologies as well as computational and statistical tools for translational bioinformatics in the areas of gene transcription and regulation, including the tools for next generation sequencing analyses, alternative spicing, the modeling of signaling pathways, network analyses in predicting disease genes, protein and gene expression data integration, and the influence of genetic variation such as single nucleotide polymorphisms on gene expression in complex human diseases etc. The book is useful for researchers and students in the field of molecular biology, clinical biology and bioinformatics, and physicians etc. Dr. Wu is assistant professor in the Vivian L. Smith Department of Neurosurgery, University of Texas Health Science Centre, Houston, USA.
