Multiple Inert Gas Elimination Technique (MIGET)

Autor: Susan R. Hopkins, Peter D. Wagner

Limbă:

Legare: Copertă tare

Editura: Springer-Verlag New York Inc.

Disponibilitate: În depozitul extern

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The Multiple Inert Gas Elimination Technique (MIGET) is a complex methodology involving specialized...

Informații despre carte

Autor

Susan R. Hopkins, Peter D. Wagner

Limbă

engleză

Legare

Carte - Copertă tare

Publicat

2017

Pagini

329

EAN

9781493974405

ISBN

1493974408

Enbook ID

16830157

Editura

Springer-Verlag New York Inc.

Greutate

6387

Dimensiuni

155 x 235 x 24

Descriere completă

The Multiple Inert Gas Elimination Technique (MIGET) is a complex methodology involving specialized gas chromatography and sophisticated mathematics developed in the early 1970's. Essentially, nobody possesses knowledge of all its elements except for its original developers, and while some practical and theoretical aspects have been published over the years, none have included the level of detail that would be necessary for a potential user to adopt and understand the technique easily. This book is unique in providing a highly detailed, comprehensive technical description of the theory and practice underlying the MIGET to help potential users set up the method and solve problems they may encounter. But it is much more than a reference manual - it is a substantial physiological and mathematical treatise in its own right. It also has a wide applicability - there is extensive discussion of the common biological problem of quantitative inference. The authors took measured whole-lung gas exchange variables, and used mathematical procedures to infer the distribution of ventilation and blood flow from this data. In so doing, they developed novel approaches to answer the question: What are the limits to what can be concluded when inferring the inner workings from the "black box" behavior of a system? The book details the approaches developed, which can be generalized to other similar distributed functions within tissues and organs. They involve engineering approaches such as linear and quadratic programming, and uniquely use mathematical tools with biological constraints to obtain as much information as possible about a "black box" system. Lastly, the book summarizes the hundreds of research papers published by a number of groups over the decades in a way never before attempted in order to marshal the world's literature on the topic and to provide in one place the wealth of important discoveries, both physiological and clinical, enabled by the technique.

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