"Synthese von IMIDs®"

Name: "Synthese von IMIDs®"
Brand: VDM Verlag Dr. Müller
SKU: 9783639193367
Price: 253.46 RON
Availability: InStock

Synthese von den immunmodulatorischen Substanzen Revlimid, Actimid und Thalidomid

Autor: Heinz Lange

Limbă:

Legare: Carte broșată

Editura: VDM Verlag Dr. Müller

Disponibilitate: La editor doar la comandă

Expediem în 17-27 zile

253.46 lei

The purpose of this diploma thesis was the synthesis of three different IMIDs Thalidomid, Revlimid a...

Informații despre carte

Autor

Heinz Lange

Limbă

germană

Legare

Carte - Carte broșată

Publicat

2009

Pagini

EAN

9783639193367

Enbook ID

06827428

Editura

VDM Verlag Dr. Müller

Greutate

106

Dimensiuni

150 x 220 x 4

Descriere completă

The purpose of this diploma thesis was the synthesis of three different IMIDs Thalidomid, Revlimid and Actimid. The representation of Thalidomid occurered by three different ways and the conversion of isobenzfuran-1,3-dione and 2,6-dioxopiperidin-3-aminium bromide brought the best yield in DMF and triethylamine. Two other synthesis ways could be carried out which also led to the end product Thalidomid, but in doing so, the yield was lower. Once the open-chained glutamine acid was, in first step, converted with the isobenzfuran-1,3-dione to the glutamine acid derivate and afterwards the ring end carried out by the 2,6-dioxotetrahydro- 2H-pyran derivate and the glutamine derivate. In the third synthesis way both source materials from the first reaction guidance were heated up with formic acid under backflow. Likewise, to synthesis the IMID Revlimid several reaction guidance were carried out. The synthesis way with the highest yield proceeded via the alkylation with following ring end to the Amid with 2,6-dioxopiperidin-3-aminium bromide and methyl 2-(bromomethyl)-3- nitrobenzoate.

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"Synthese von IMIDs®"

Synthese von den immunmodulatorischen Substanzen Revlimid, Actimid und Thalidomid

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Descriere completă

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