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The role of free radicals and antioxidants is receiving constant attention in relation to disease processes and reaches into many aspects of medicine. As of February 28, 2011 a search on PubMed indicates there are approximately 1400 references to psychiatry coupled with antioxidants. In addition, there are 550 papers related to cognition / behavior and 239 related to schizophrenia. These articles are primarily concerned with the use of predictive biomarkers and the effect of multiple antioxidants administered for therapeutic intervention. There is increasing evidence that oxidative stress is a causative, or at least a supportive factor in several disorders affecting abnormal behavior. Oxidative stress also plays a regulatory role in transcription, signal transduction, gene expression and mitochondrial function, membrane trafficking and post-synthetic damage.
