Structural Plasticity of Dendritic Spines

Name: Structural Plasticity of Dendritic Spines
Brand: VDM Verlag
SKU: 9783639129816
Price: 274.28 RON
Availability: InStock

A Computational Study

Autor: Muhammad Dur-e-Ahmad

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Editura: VDM Verlag

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274.28 lei

The geometry of a dendritic spine influences the §dynamics of calcium in the spine and is regulated...

Informații despre carte

Autor

Muhammad Dur-e-Ahmad

Limbă

engleză

Legare

Carte - Carte broșată

Publicat

2009

Pagini

112

EAN

9783639129816

ISBN

3639129814

Enbook ID

06821729

Editura

VDM Verlag

Greutate

177

Dimensiuni

152 x 229 x 7

Descriere completă

The geometry of a dendritic spine influences the §dynamics of calcium in the spine and is regulated §during synaptic plasticity. For instance, a moderate §rise in calcium can cause elongation, while a very §large increase in calcium causes fast shrinkage and §the eventual collapse of a spine. In this book, we §presented computational models for the calcium §mediated spine-stem restructuring. This expansion §and shrinkage depends on the frequency of the §synaptic input to a spine as well as the activation §of the calcium channels located on the spine head §membrane. We are using computational studies to §investigate the changes in spine density and §structure for a variety of synaptic inputs of §different frequencies. In particular, we are using §the models to investigate the mechanisms underlying §changes in spine density and morphology and the role §of spine plasticity in long-term depression (LTD) §and long-term potentiation (LTP). Finally, for the §integration of our system, we also presented two new §algorithms based on spectral collocation method for §these types of problems and compare the results with §the conventional finite difference methods.

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Structural Plasticity of Dendritic Spines

A Computational Study

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Descriere completă

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