Sphingolipid Biochemistry

Name: Sphingolipid Biochemistry
Brand: Springer-Verlag New York Inc.
SKU: 9781475703986
Price: 275.53 RON
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Autor: Julian N. Kanfer, Sen-itiroh Hakomori

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Editura: Springer-Verlag New York Inc.

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Interest in and emphasis upon different aspects of the sphingolipids have, in general, followed the...

Informații despre carte

Autor

Julian N. Kanfer, Sen-itiroh Hakomori

Limbă

engleză

Legare

Carte - Carte broșată

Publicat

2012

Pagini

485

EAN

9781475703986

ISBN

1475703988

Enbook ID

06797788

Editura

Springer-Verlag New York Inc.

Greutate

942

Dimensiuni

178 x 254 x 27

Descriere completă

Interest in and emphasis upon different aspects of the sphingolipids have, in general, followed the biochemical developments of the day. The early inves tigators were preoccupied principally with the isolation of "pure" compounds and structural elucidation. This historical perspective is found in the discus sion presented in Chapter 1 (Section 1. 1. 2 and Table III). Still, the isolation and structural characterization of glycolipids are the basic foundation of all our knowledge of enzymology, immunology, and cell biology. Recent infor mation obtained on structure has greatly affected the interpretation of various phenomena related to glycolipids. New structures suggest a new role of gly colipids as antigens and receptors. Ten years ago, only four neutral glycolipids and two gangliosides were known in human erythrocytes. We now know structures of at least twenty additional neutral glycolipids and ten additional gangliosides in human erythrocytes that are known to be important blood group, heterophil, and autoantigens. Erythrocytes are only one example of a cell type whose glycolipid profile has been extensively studied. Our defective knowledge in immunology and cell biology may be due to incomplete un derstanding of structural chemistry. Modern methodology based on methyla tion analysis, mass spectrometry, and enzymatic degradation has supple mented classical analysis based on clorimetry. Nuclear magnetic resonance spectroscopy is still in the development stage, but will eventually replace var ious chemical analyses. However, important future studies should be directed toward elucidating the organizational structure of glycolipids in membranes.

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