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Carte Setd6 Mario Richter

Setd6

A Novel Histone Lysine Mono-Methyltransferase

Autor: Mario Richter
Limbă: engleză
Legare: Carte broșată
Editura: Sudwestdeutscher Verlag Fur Hochschulschriften AG
Disponibilitate: În depozitul extern
Expediem în 8-11 zile
336.14 lei
In this work we characterize a novel histone lysine §mono-methyltransferase called Setd6. By enzymat...

Informații despre carte

Autor
Mario Richter
Limbă
engleză
Legare
Carte - Carte broșată
Publicat
2009
Pagini
132
EAN
9783838105758
ISBN
3838105753
Enbook ID
07064947
Editura
Sudwestdeutscher Verlag Fur Hochschulschriften AG
Greutate
186
Dimensiuni
152 x 229 x 7

Descriere completă

In this work we characterize a novel histone lysine §mono-methyltransferase called Setd6. By enzymatic §assays we demonstrate that this protein is capable §of modifying histone H1, H2A, H3 and H4. For all but §the linker histone H1 we furthermore determine the §exact residue methylated. In mouse NIH 3T3 cells a §reduction of the Setd6 protein level leads to a §misregulation of a set of genes including several §that are important for the regulation of §differentiation and cell line commitment. Amongst §those is a segregated co-regulator of the Wnt §signaling pathway. In immunoprecipitation §experiments we identify specific interactors of §Setd6 in murine immortalized fibroblasts and murine §embryonic stem cells. Again we find proteins that §are important for the Wnt signaling pathway. Taken §together the enzymatic activity and the in cell §results we conclude that we identified a novel §histone lysine mono-methyltransferase possibly §involved in the maintenance of cell line identity §and acting as antagonist of the histone §acetyltransferase Tip60 as both enzymes target the §exact same residues.

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