Sendai Virus Vector

Name: Sendai Virus Vector
Brand: Springer Verlag, Japan
SKU: 9784431545552
Price: 829.32 RON
Availability: InStock

Advantages and Applications

Autor: Yoshiyuki Nagai

Limbă:

Legare: Copertă tare

Editura: Springer Verlag, Japan

Disponibilitate: În depozitul extern

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829.32 lei

Sendai virus (SeV) is not just a mouse pathogen but is evolving into a cutting-edge component of bio...

Informații despre carte

Autor

Yoshiyuki Nagai

Limbă

engleză

Legare

Carte - Copertă tare

Publicat

2014

Pagini

210

EAN

9784431545552

ISBN

4431545557

Enbook ID

02075969

Editura

Springer Verlag, Japan

Greutate

466

Dimensiuni

158 x 243 x 14

Descriere completă

Sendai virus (SeV) is not just a mouse pathogen but is evolving into a cutting-edge component of biotechnology. SeV reverse genetics originating from a pure academic need to settle long-held questions in the biology and pathogenicity of nonsegmented negative strand RNA viruses (Mononegavirales) is about to bear the impressive fruit of multipurpose cytoplasmic (nonintegrating) RNA vectors. This book brings together in one source the SeV biology revealed by conventional approaches and reverse genetics, the methods to construct the first-generation SeV vector and to generate safer versions, and the applications in medical settings that have left or are about to leave the laboratory bench. The applications, which already are diverse and have high medical impact, include use as vaccine vectors against AIDS and respiratory virus infections, creation of BioKnife to resect malignant tumors, induction of footprint (transgene) free pluripotent stem cells, and gene therapy for peripheral arterial disease (critical limb ischemia). These achievements which are just a few of many examples were attainable only after rigorously incorporating the rich knowledge of SeV biology that has accumulated during the several decades since the discovery of the virus. Application of SeV vector is certain to expand greatly because of its extremely high performance in transgene expression and its remarkable target cell breadth.

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Sendai Virus Vector

Advantages and Applications

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