Selective Estrogen Receptor Modulators

Name: Selective Estrogen Receptor Modulators
Brand: Humana Press Inc.
SKU: 9780896039124
Price: 892.26 RON
Availability: InStock

Autor: Andrea Manni, Michael Verderame

Limbă:

Legare: Copertă tare

Editura: Humana Press Inc.

Disponibilitate: În depozitul extern în cantități mici

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Hormone replacement therapy with selective estrogen receptor modulators (SERMs) promises the highly...

Informații despre carte

Autor

Andrea Manni, Michael Verderame

Limbă

engleză

Legare

Carte - Copertă tare

Publicat

2002

Pagini

374

EAN

9780896039124

ISBN

0896039129

Enbook ID

01400899

Editura

Humana Press Inc.

Greutate

2100

Dimensiuni

178 x 254 x 25

Descriere completă

Hormone replacement therapy with selective estrogen receptor modulators (SERMs) promises the highly desirable benefits of estrogen and progesterone replacement therapy, while avoiding their associated risks of breast and uterine cancer, gallbladder disease, and weight gain. In Selective Estrogen Receptor Modulators: Research and Clinical Applications, leading experimental and clinical researchers from a wide range of disciplines present a wealth of fresh scientific information on the biochemistry, molecular biology, pharmacology, and clinical activity of SERMs. The basic science chapters of the book focus-with an eye to the development of the ideal SERM-on the complex mechanisms of estrogen action, including ligand-dependent conformational changes in alpha and beta, and the recruitment of coactivators and corepressors which modulate the estrogen receptor transcriptional activity and contribute to its crosstalk with growth factor signaling. The clinical presentations review the data accumulated on currently available SERMs, primarily tamoxifen and raloxifene, in cancer treatment and prevention, as well as their effects on the reproductive, vascular, skeletal, and central nervous systems. A novel approach to menopause-related health issues is also provided for women with and without a previous diagnosis of localized breast cancer. §Multidisciplinary and state-of-the-art, Selective Estrogen Receptor Modulators: Research and Clinical Applications provides experimentalists and clinicians alike a comprehensive overview of the basic mechanisms of estrogen and SERMs action, as well as evidence-based guidelines for their clinical use in postmenopausal women.

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