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Carte Retroviruses Ronald Swanstrom

Retroviruses

Strategies of Replication

Autor: Ronald Swanstrom, Peter K. Vogt
Limbă: engleză
Legare: Carte broșată
Editura: Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
Disponibilitate: În depozitul extern
Expediem în 5-8 zile
551.23 lei
Among the first diseases for which a viral etiology was esta blished were tumors, lymphomas, and sar...

Informații despre carte

Autor
Ronald Swanstrom, Peter K. Vogt
Limbă
engleză
Legare
Carte - Carte broșată
Publicat
2011
Pagini
259
EAN
9783642752209
ISBN
3642752209
Enbook ID
07074231
Editura
Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
Greutate
429
Dimensiuni
155 x 235 x 16

Descriere completă

Among the first diseases for which a viral etiology was esta blished were tumors, lymphomas, and sarcomas in chickens, shown by Ellermann and Bang (1908) and Rous (1910) to be transmissible with cell-free filtrates. The broad significance of these discoveries was not fully recognized at first, mainly because chickens were perceived as too distanly related to humans to provide useful and relevant models for human disease. Change came slowly. In 1936 Bittner found that a viral agent is involved in the causation of mammary cancer in mice, and in 1957 Gross discovered the first murine leukemia virus. In the years following numerous tumor-inducing viruses, infecting all classes of verte brates, were isolated. The decisive impulse for the development of the RNA tumor virus field sprang from advances in cell culture. In 1958 Temin and Rubin, following initial observations of Manaker and Groupe, worked out the conditions for virus-induced tumori genic transformation in cell culture and made this transform ation the basis for a quantitative assay of viral infectivity and oncogenicity. The genetic and cell biological studies that grew out of Rubin's and Temin's groundwork quickly brought into focus two puzzling problems: a requirement for DNA synthesis early in the lifecycle of the RNA tumor viruses, and the existence of genetic information in the virus that is needed for oncogenesis but not for virus reproduction.

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