Retroviral Insertion and Oncogene Activation

Name: Retroviral Insertion and Oncogene Activation
Brand: Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
SKU: 9783642765261
Price: 276.6 RON
Availability: InStock

Autor: Hsing-Jien Kung, Peter K. Vogt

Limbă:

Legare: Carte broșată

Editura: Springer-Verlag Berlin and Heidelberg GmbH & Co. KG

Disponibilitate: În depozitul extern

Expediem în 5-8 zile

276.60 lei

An integrated retrovirus effectively becomes part of the cellular genome, but with the difference th...

Informații despre carte

Autor

Hsing-Jien Kung, Peter K. Vogt

Limbă

engleză

Legare

Carte - Carte broșată

Publicat

2011

Pagini

179

EAN

9783642765261

ISBN

3642765262

Enbook ID

07074229

Editura

Springer-Verlag Berlin and Heidelberg GmbH & Co. KG

Greutate

306

Dimensiuni

155 x 235 x 11

Descriere completă

An integrated retrovirus effectively becomes part of the cellular genome, but with the difference that the virus to a large extent retains control over its own expression through nontranslated sequences in the long terminal repeat (L TR). Some retroviruses also code for nonstructural proteins that further regulate proviral expression. Integration changes the cell genome; it adds viral genes, and in the case of transducing retroviruses also adds cell-derived oncogenes that have been incorporated into the viral genome. Integration can also have consequences for cellular genes. The transcriptional signals in a provirus can activate expression of neighboring cellular genes; the integration even can disrupt and thus inactivate cellular genes. These effects of retroviral genomes take place in cis; they are referred to as insertional mutagenesis and are the subject of this volume. Almost 10 years have passed since W. Hayward, S. Astrin, and their colleagues found that in B cell lymphomas of chickens, induced by avian leukosis virus, transcription of the cellular proto-oncogene myc was upregulated through the integration of a complete or partial provirus in its vicinity. This landmark discovery suggested a mechanism by which retro viruses that do not carry cellular oncogenes in their genome ("nonacute retroviruses") can cause cancer. It contributed the first evidence for the carcinogen potential of oncogenes that are not part of a viral genome.

S-ar putea să te intereseze

Clienții care au cumpărat această carte au mai cumpărat și

Cele mai căutate

Categories

Authors

Publishers

Produse

Produse

Cele mai căutate

Categories

Authors

Publishers

Produse

Produse

Retroviral Insertion and Oncogene Activation

Informații despre carte

Descriere completă

S-ar putea să te intereseze

Clienții care au cumpărat această carte au mai cumpărat și