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Retrotransposition, Diversity and the Brain

Name: Retrotransposition, Diversity and the Brain
Brand: Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
SKU: 9783540749653
Price: 550.75 RON
Availability: InStock

Autor: Fred Gage, Yves Christen

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Legare: Copertă tare

Editura: Springer-Verlag Berlin and Heidelberg GmbH & Co. KG

Disponibilitate: În depozitul extern

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Retroelements are ancient mobile DNA found in most organisms. Long dismissed as useless, selfish or...

Informații despre carte

Autor

Fred Gage, Yves Christen

Limbă

engleză

Legare

Carte - Copertă tare

Publicat

2007

Pagini

123

EAN

9783540749653

ISBN

3540749659

Enbook ID

01569240

Editura

Springer-Verlag Berlin and Heidelberg GmbH & Co. KG

Greutate

377

Dimensiuni

155 x 235 x 13

Descriere completă

Retroelements are ancient mobile DNA found in most organisms. Long dismissed as useless, selfish or "junk" DNA, they were thought to be mere intracellular parasites from our distant evolutionary past. Together with their mutant relatives, L1 sequences constitute almost 50% of the mammalian genome. L1s can retrotranspose in a defined window of the neuronal differentiation, changing the genetic information in single neurons in a "random" fashion, allowing the brain to develop in distinct different ways. Such strategy contributes to expand the number of functionally distinct neurons that could be produced from a given stem cell gene pool. This characteristic of variety and flexibility may contribute to the uniqueness of an individual brain, even between genetically identical twins. These mobile elements may be part of conserved core process responsible for evoking facilitated complex non-random phenotypical variation on which selection may act. A detailed understanding of the basic mechanisms of L1 activity may shed light on one possible mechanism for generating neural diversity.§The book results from a fascinating and stimulating exchange of ideas at the interface of the complexity of brain organization and function, the mechanisms for generating diversity and genetic mobility. This meeting of leading geneticists, molecular biologists and neuroscientists was organized by the Fondation IPSEN. Its ambitious goal was to expand the current limits of research in neurobiology not only to the benefit of those interested in the cellular and molecular processes but also for the understanding of high-level cognitive functions and the understanding of complex mental diseases. The reader can judge how far the book achieves this.

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