Renal Cell Carcinoma

Name: Renal Cell Carcinoma
Brand: Springer, Berlin
SKU: 9784431555308
Price: 860.71 RON
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Molecular Features and Treatment Updates

Autor: Mototsugu Oya

Limbă:

Legare: Copertă tare

Editura: Springer, Berlin

Disponibilitate: În depozitul extern

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Renal Cell Carcinoma: Molecular Features and Treatment Updates provide a comprehensive review of dia...

Informații despre carte

Autor

Mototsugu Oya

Limbă

engleză

Legare

Carte - Copertă tare

Publicat

2015

Pagini

381

EAN

9784431555308

ISBN

4431555307

Enbook ID

09226491

Editura

Springer, Berlin

Greutate

823

Dimensiuni

159 x 24 x 20

Descriere completă

Renal Cell Carcinoma: Molecular Features and Treatment Updates provide a comprehensive review of diagnosis and treatments of renal cell carcinoma (RCC) for practitioners and researchers with an interest in this disease. A major aim of the book is to present the most important and most recent advances in molecular bases and targeted therapy for this neoplasm. The remarkable resistance to chemotherapy and radiotherapy and the minimum contribution of cancer genes that commonly mutate in other adult epithelial cancers have made RCC highly distinct from other types of solid neoplasms. In the past decade, however, treatment options for RCC have been expanding and moving quickly toward laboratory-based and molecular-targeted therapies. The United States Food and Drug Administration has approved four tyrosine-kinase inhibitors (TKIs), including sorafenib, sunitinib, pazopanib and axitinib and two mTOR inhibitors, including everolimus and temsirolimus. Advances in RCC therapy also have brought novel treatment options to other types of cancer, such as a TKI for hepatocellular carcinoma and gastrointestinal tumors, as well as mTOR inhibitors to progressive neuroendocrine tumors of pancreatic origin and breast cancer, suggesting that RCC is no longer an "orphan disease" in the field of molecular oncology. Additional topics covered in the book include pharmacokinetics and pharmacodynamics in molecular-targeted agents and the putative mechanism of resistance to anti-angiogenic agents, such as intratumoral heterogeneity or cancer stem cell population. This volume provides the latest and most useful information for all readers who are eagerly devoted to curing renal cell carcinoma.

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Renal Cell Carcinoma

Molecular Features and Treatment Updates

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