Protein Carbonylation - Principles, Analysis, and Biological implications

Autor: Joaquim Ros, Rodney Levine

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Legare: Copertă tare

Editura: John Wiley and Sons Ltd

Disponibilitate: În depozitul extern în cantități mici

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Protein carbonylation has attracted the interest of a great number of laboratories since the pioneer...

Informații despre carte

Autor

Joaquim Ros, Rodney Levine

Limbă

engleză

Legare

Carte - Copertă tare

Publicat

2017

Pagini

416

EAN

9781119074915

ISBN

9781119074915

Enbook ID

14527354

Editura

John Wiley and Sons Ltd

Greutate

664

Dimensiuni

161 x 234 x 26

Descriere completă

Protein carbonylation has attracted the interest of a great number of laboratories since the pioneering studies at the Earl Stadtman's lab at NIH started in early 1980s. Since then, detecting protein carbonyls in oxidative stress situations became a highly efficient tool to uncover biomarkers of oxidative damage in normal and altered cell physiology. In this book, research groups from several areas of interest have contributed to update the knowledge regarding detection, analyses and identification of carbonylated proteins and the sites where these modifications occur. The scientific community will benefit from these reviews since they deal with specific, detailed technical approaches to study formation and detection of protein carbonyls. Moreover, the biological impact of such modifications in metabolic, physiologic and structural functions and, how these alterations can help understanding the downstream effects on cell function are discussed. * Oxidative stress occurs in all living organisms and affects proteins and other macromolecules: Protein carbonylation is a measure of oxidative stress in biological systems * Mass spectrometry, fluorescent labelling, antibody based detection, biotinylated protein selection and other methods for detecting protein carbonyls and modification sites in proteins are described * Aging, neurodegenerative diseases, obstructive pulmonary diseases, malaria, cigarette smoke, adipose tissue and its relationship with protein carbonylation * Direct oxidation, glycoxidation and modifications by lipid peroxidation products as protein carbonylation pathways * Emerging methods for characterizing carbonylated protein networks and affected metabolic pathways

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Protein Carbonylation - Principles, Analysis, and Biological implications

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