Prostaglandins and Immunity

Name: Prostaglandins and Immunity
Brand: Kluwer Academic Publishers
SKU: 9780898387230
Price: 890.91 RON
Availability: InStock

Autor: James S. Goodwin

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Legare: Copertă tare

Editura: Kluwer Academic Publishers

Disponibilitate: În depozitul extern în cantități mici

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890.91 lei

Prostaglandins, Leukotrienes, and Cancer is a multi-volume series that will focus on an emerging are...

Informații despre carte

Autor

James S. Goodwin

Limbă

engleză

Legare

Carte - Copertă tare

Pagini

210

EAN

9780898387230

ISBN

089838723X

Enbook ID

01401291

Editura

Kluwer Academic Publishers

Greutate

499

Dimensiuni

155 x 235 x 14

Descriere completă

Prostaglandins, Leukotrienes, and Cancer is a multi-volume series that will focus on an emerging area of cancer research. In 1968, R.H. Williams first reported that elevated prostaglandin levels are present in human medullary car cinoma. Since that time, the concept that arachidonic acid metabolites may be in volved in cancer has expanded to include every aspect of the disease from cell transformation through metastasis. Prostaglandins and leukotrienes are generic terms used to describe a family of bioactive lipids produced from unsaturated fatty acids (principally from arachidonic acid) via the cyclooxygenase and lipoxygenase pathways, respec tively. Cyclooxygenase products consist of diverse products such as prosta glandin E2 (PGE2), prostacyclin (PGI2) and thromboxane A2 (TXA2), whereas lipoxygenase products consist of hydroperoxy fatty acids and mono-, di-and tri-hydroxy acids including leukotrienes. The precursor fatty acids for the cyclooxygenase and lipoxygenase pathways are present in cellular phospholipids. This finding established an important control point in their biosynthesis-the release of substrate. This occurs in response to numerous stimuli that act at the cell surface. Dr. Bengt Samuelsson's extensive study of the metabolism of pros taglandins indicated that they are rapidly inactivated on a single pass through pulmonary circulation. Thus, they cannot act as circulating hormones and appear to be made on demand in or in the vicinity of target tissues leading to the concept that prostaglandins are local hormones or autocoids.

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