Poly(ADP-Ribose) Polymerase

Methods and Protocols

Autor: Alexei V. Tulin

Limbă:

Legare: Carte broșată

Editura: Humana Press Inc.

Disponibilitate: În depozitul extern

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This book presents multiple new and classical methods for studying the vital poly-ADP-ribose (pADPr)...

Informații despre carte

Autor

Alexei V. Tulin

Limbă

engleză

Legare

Carte - Carte broșată

Publicat

2018

Pagini

528

EAN

9781493983612

Enbook ID

20091964

Editura

Humana Press Inc.

Greutate

1031

Dimensiuni

178 x 254 x 30

Descriere completă

This book presents multiple new and classical methods for studying the vital poly-ADP-ribose (pADPr) pathway. Beginning with techniques for the detection and quantification of the product of poly(ADP-ribose) polymerase (PARP) enzymatic activity and detection of variation in pADPr production during the cell cycle, the volume continues with sections on the identification of pADPr protein acceptors, methods focusing on studying molecular mechanisms of PARP functions in eukaryotic cells, particularly those involved in control of DNA repair and oxidative stress, as well as in expression regulation, approaches to the in vitro reconstitution of PARP-1 interaction with chromatin, the development and testing of small molecule PARP inhibitors, and the functions of understudied members of PARP family. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Poly(ADP-Ribose) Polymerase: Methods and Protocols, Second Edition serves as an ideal companion to the first edition for scientists whose investigations involve this important pathway. The chapter 'Identifying and Validating Tankyrase Binders and Substrates: A Candidate Approach' is published open access under a CC BY 4.0 license.

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Poly(ADP-Ribose) Polymerase

Methods and Protocols

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