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Phase Separation in Living Cells

Name: Phase Separation in Living Cells
Brand: Springer, Berlin
SKU: 9789819948857
Price: 935.0 RON
Availability: InStock

Benefits and Risks

Autor: Riki Kurokawa

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Legare: Copertă tare

Editura: Springer, Berlin

Disponibilitate: În depozitul extern

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935.00 lei

This book presents the latest cutting-edge research on phase separation. It discusses the benefits a...

Informații despre carte

Autor

Riki Kurokawa

Limbă

engleză

Legare

Carte - Copertă tare

Publicat

2023

Pagini

240

EAN

9789819948857

Enbook ID

43680706

Editura

Springer, Berlin

Greutate

770

Dimensiuni

155 x 235

Descriere completă

This book presents the latest cutting-edge research on phase separation. It discusses the benefits and risks of phase separation for living cells from the perspectives of physics, chemistry, biology, and medicine.Phase separation is a physico-chemical process that induces a single solution of solvent and intrinsically disordered proteins (IDPs) to separate into two phases, one phase containing only solvent and the other containing IDPs in the solvent. A key molecule in phase separation is the intrinsically disordered region (IDR) proteins (IDPs), mostly comprised of RNA-binding proteins (RBPs). One of the major roles of phase separation is to generate condensates, membrane-less organelles including stress granule, Cajal body, and nucleolus.Biological actions of phase separation in various aspects of science have received increasing attention in recent years. The book consists of four parts; Part I on physics and chemistry includes topics on structural biology of RBP FUS/TLS and chaperone for phase separation, computational approach of phase separation, and chemistry of G-quadruplex of DNA and RNA. Part II on molecular biology presents molecular mechanism of IDR sequence phase separation and potential cellular function of these labile fibers, formation of membrane-less organelles, and roles of noncoding RNAs in phase separation. Part III on biology covers topics from nuclear pore complex, developmental biology regarding force-dependent remodeling, and neurobiology and higher order brain functions. Finally, Part IV on medicine presents condensates and cancer therapy, pathogenesis of neurodegenerative diseases based on IDPs, and responses of microglia to amyloid. The last chapter highlights the latest topic on how the SARS-Cov-2 virus takes advantage of phase separation for its infections.This book brings together the studies of phase separation in each area in a single volume. The comprehensive approach provides new insights to the research and will benefit the readers by responding to the emerging needs for understanding phase separation.

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Phase Separation in Living Cells

Benefits and Risks

Informații despre carte

Descriere completă

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