Peptides as Immunogens

Name: Peptides as Immunogens
Brand: Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
SKU: 9783642714429
Price: 550.27 RON
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Autor: Hilary Koprowski, Fritz Melchers

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Editura: Springer-Verlag Berlin and Heidelberg GmbH & Co. KG

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The humoral response of the immune system to a foreign antigen usually requires the recognition of t...

Informații despre carte

Autor

Hilary Koprowski, Fritz Melchers

Limbă

engleză

Legare

Carte - Carte broșată

Publicat

2011

Pagini

EAN

9783642714429

ISBN

9783642714429

Enbook ID

06623655

Editura

Springer-Verlag Berlin and Heidelberg GmbH & Co. KG

Greutate

189

Dimensiuni

170 x 244 x 6

Descriere completă

The humoral response of the immune system to a foreign antigen usually requires the recognition of two antigenic determinants. The one, called the carrier, is recognized by T-Iymphocytes, the other, called the hapten, by B-Iympho cytes. As a consequence, T - and B-Iymphocytes proliferate, B-Iymphocytes produce hapten-specific antibodies, and the system develops memory to the antigens. It was long thought that antigens would form a bridge to mediate the cooperation of T - and B-Iymphocytes. However, it now appears that antigens are broken down to fragments which then act as carrier determinants for T -lymphocytes. The cells which originally process antigen are called an tigen-presenting cells. They have phagocytic properties. They can take up and degrade antigens, in the case of pro teins to peptides. The peptides of protein antigens reappear on the surface of the antigen-presenting cells, where they must become associated with membrane proteins encoded by genes of the major histocompatibility complex (MHC) in order to be recognized by T-Iymphocytes. To activate helper T-Iym phocytes which cooperate in antibody responses, MHC class II molecules have to be expressed on the surface of the antigen-presenting cells. Once T -lymphocytes have be come activated, they are ready to cooperate with B cells.

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