Next Generation Kinase Inhibitors

Name: Next Generation Kinase Inhibitors
Brand: Springer Nature Switzerland AG
SKU: 9783030482824
Price: 679.92 RON
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Moving Beyond the ATP Binding/Catalytic Sites

Autor: Paul Shapiro

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Legare: Copertă tare

Editura: Springer Nature Switzerland AG

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Protein kinases are fascinating enzymes that maintain the proper function of nearly every task perfo...

Informații despre carte

Autor

Paul Shapiro

Limbă

engleză

Legare

Carte - Copertă tare

Publicat

2020

Pagini

217

EAN

9783030482824

Enbook ID

32622224

Editura

Springer Nature Switzerland AG

Greutate

518

Dimensiuni

155 x 235 x 18

Descriere completă

Protein kinases are fascinating enzymes that maintain the proper function of nearly every task performed by the cells of the human body. By extracting a phosphate from the energy molecule ATP and linking it to another protein, protein kinases alter the structure and ultimate function of other proteins. In this way, protein kinases help monitor the extracellular environment and integrate signaling cues that, for the most part, are beneficial for human health and survival. However, protein kinases are often dysregulated and responsible for the initiation and progression of many types of cancers, inflammatory disorders, and other diseases. Thus, decades of research have revealed much about how protein kinases are regulated and approaches to inhibit these enzymes to treat disease. However, nearly 30 years since the identification of the first clinically beneficial small molecule protein kinase inhibitor, there are only a few examples where these drugs provide sustained and durable patient responses. The goal of this book is to provide biomedical scientists, graduate, and professional degree students insight into different approaches using small molecules to block specific protein kinase functions that promote disease.

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Next Generation Kinase Inhibitors

Moving Beyond the ATP Binding/Catalytic Sites

Informații despre carte

Descriere completă

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