Neuropilin

Name: Neuropilin
Brand: Springer-Verlag New York Inc.
SKU: 9781461349327
Price: 824.66 RON
Availability: InStock

From Nervous System to Vascular and Tumor Biology

Autor: Dominique Bagnard

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Legare: Carte broșată

Editura: Springer-Verlag New York Inc.

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Cell adhesion is one of the most important properties controlling embryonic development. Extremely p...

Informații despre carte

Autor

Dominique Bagnard

Limbă

engleză

Legare

Carte - Carte broșată

Publicat

2012

Pagini

142

EAN

9781461349327

ISBN

9781461349327

Enbook ID

06617922

Editura

Springer-Verlag New York Inc.

Greutate

272

Dimensiuni

155 x 235 x 10

Descriere completă

Cell adhesion is one of the most important properties controlling embryonic development. Extremely precise cell-cell contacts are established according to the nature of adhesion molecules that are expressed on the cell surface. The identifica tion of several families of adhesion molecules, well conserved throughout evolu tion, has been the basis of a considerable amount of work over the past 20 years that contributed to establish functions of cell adhesion in almost all organs. Nowadays, cell adhesion molecules are not just considered as cellular glue but are thought to play critical roles in cell signaling. Their ability to influence cell proliferation, mi gration, or differentiation depends on both cell surface adhesion properties and acti vation of intracellular pathways. The next challenge will be to understand how these molecules interact with each other to ensure specific functions in the morphogen esis of very sophisticated systems. Indeed, by exploring the cellular and molecular mechanisms of nervous system development, the group of H. Fujisawa in Japan identified in 1987 an adhesion molecule, neuropilin, highly expressed in the neuro pile of amphibian optic tectum. Ten years later, two groups discovered that neuropilin is a receptor for guidance signals of the semaphorin family. Axon guidance is a critical step during brain development and the mechanisms ensuring growth cone navigation are beginning to be well understood. The semaphorins are bifunctional signals defining permissive or inhibitory pathways sensed by the growth cone.

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Neuropilin

From Nervous System to Vascular and Tumor Biology

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