Nanocarriers Based Colon Targeting: Design, Development, Mechanism and Case Studies unveils a ground-breaking exploration of nanotechnology's potential in revolutionizing drug delivery for colon-related ailments. Nowadays, an array of colonic diseases, including colorectal cancer, colonic polyps, ulcerative colitis, and inflammatory bowel syndrome, poses significant medical challenges. Conventional methods to deliver drugs to this system proves difficult, with limited efficacy and notable side effects. This book delves into the intricate complexities of colonic diseases, their pathophysiology, and epidemiology, to support pharmaceutical scientists in designing better drug delivery systems. Providing a comprehensive overview of the area, the chapters elucidate diverse targeting strategies, from time-dependent to microbiota-based drug delivery systems and explore receptor-based and magnetically assisted delivery mechanisms. Case studies dissected the working mechanisms behind polymeric nanoparticles, polymersomes, polymeric micelles, solid lipid nanoparticles, and other nanocarrier systems tailored for colon targeting. Additionally, the book delves into cutting-edge topics such as gold nanoparticles, supramagnetic iron oxide nanoparticles, and protein-peptide-based nanoparticles, highlighting their mechanisms, applications, and potential toxicities. Merging an overview of colonic pathophysiology with in-depth reviews of each nanomaterial used for drug delivery and practical case studies, "Nanocarriers Based Colon Targeting" is a complete reference for pharmaceutical scientists involved in elevating drug delivery precision and therapeutic efficacy to this organ system. Toxicologists, material scientists, research physicians and regulators can also benefit from the case studies developed by expert authors.
- Introduces different colonic diseases and their pathophysiology
- Explains the mechanism of action of different nanocarriers in colon targeting
- Presents case studies of different nanocarriers in colon targeting
