Multichain Immune Recognition Receptor Signaling

Name: Multichain Immune Recognition Receptor Signaling
Brand: Springer-Verlag New York Inc.
SKU: 9780387097886
Price: 870.28 RON
Availability: InStock

From Spatiotemporal Organization to Human Disease

Autor: Alexander Sigalov

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Legare: Copertă tare

Editura: Springer-Verlag New York Inc.

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This book intends to assemble reviews on the progress in defining and controlling the spatiotemporal...

Informații despre carte

Autor

Alexander Sigalov

Limbă

engleză

Legare

Carte - Copertă tare

Publicat

2008

Pagini

357

EAN

9780387097886

ISBN

0387097880

Enbook ID

01380869

Editura

Springer-Verlag New York Inc.

Greutate

848

Dimensiuni

155 x 235 x 25

Descriere completă

This book intends to assemble reviews on the progress in defining and controlling the spatiotemporal organization of key events in immune cell activation. Improved understanding of MIRR-mediated signaling has a number of potential practical applications, from the rational design of drugs and vaccines to the engineering of cells for biotechnological purposes. In Section 1, spatial organization and physiological function of the MIRR family members such as T cell receptor (TCR), B cell receptor (BCR), Fc receptors, natural killer (NK) cell receptors, and platelet glycoprotein VI (GPVI) will be reviewed. Section 2 will focus on current models of MIRR-triggering and highlight modern technologies to visualize cell-cell interaction contacts such as immunological synapse and to measure protein-protein interactions in space in real time. Potential therapeutic strategies targeting the MIRR-mediated transmembrane signal transduction will be shortly reviewed in Section 3. This book will summarize our current knowledge in this field and illustrate how control of the MIRR-triggered signaling could become a potential target of medical intervention, thus bridging basic and clinical immunology.

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Multichain Immune Recognition Receptor Signaling

From Spatiotemporal Organization to Human Disease

Informații despre carte

Descriere completă

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