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Microencapsulation and Artificial Cells

Name: Microencapsulation and Artificial Cells
Brand: Humana Press Inc.
SKU: 9780896030732
Price: 891.68 RON
Availability: InStock

Autor: T. M. S. Chang

Limbă:

Legare: Copertă tare

Editura: Humana Press Inc.

Disponibilitate: În depozitul extern în cantități mici

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891.68 lei

Early studies by Pendleton and West (1) in 1932 demonstrated that urea moved from the blood into the...

Informații despre carte

Autor

T. M. S. Chang

Limbă

engleză

Legare

Carte - Copertă tare

Pagini

320

EAN

9780896030732

ISBN

0896030733

Enbook ID

01400539

Editura

Humana Press Inc.

Greutate

1750

Dimensiuni

178 x 254 x 19

Descriere completă

Early studies by Pendleton and West (1) in 1932 demonstrated that urea moved from the blood into the small intestine in uremic dogs. In 1946, Twiss and Kolff (2) showed in uremic patients that urea could be removed when an isotonic solution was perfused through an isolated in testinalloop. Since these early studies had demonstrated the presence of urea and its removal from the gastrointestinal tract, Yatzidis (3) in 1964 investigated the use of activated charcoal for the removal of uremic wastes from the intestinal tract. In addition to Yatzidis' studies with char coal, other investigations with charcoal have been unable to confirm any significant reduction in serum levels of urea, creatinine, uric acid, or guanidines (4,5) via this approach. At the same time that Yatzidis proposed the use of charcoal for re moval of nitrogenous wastes from the intestinal tract, he also proposed using charcoal in a hemoperfusion microapparatus as an effective artifi cial kidney. However, clinical studies performed with the Yatzidis char coal artificial kidney showed an adverse affect on platelets and the re lease of embolizing particles (6,7). To overcome these platelet and emboli problems, Chang's group (8) proposed the general idea of "artificial cells," Le., microcapsules con taining adsorbents. Since the charcoal particles were now encased within blood compatible membranes, they could not leave the microcapsules to cause embolism, and platelets did not now come in direct contact with the charcoal. In their early clinical hemoperfusion studies, Chang et al.