Methods and Applications in Comparative Bacterial Genomics - Studying Microevolution in Action

Name: Methods and Applications in Comparative Bacterial Genomics - Studying Microevolution in Action
Brand: VDM Verlag Dr. Mueller E.K.
SKU: 9783836475808
Price: 273.69 RON
Availability: InStock

Autor: Hans-Henrik Fuxelius

Limbă:

Legare: Carte broșată

Editura: VDM Verlag Dr. Mueller E.K.

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273.69 lei

Comparative studies of bacterial genomes generate massive amounts of information. In order to suppor...

Informații despre carte

Autor

Hans-Henrik Fuxelius

Limbă

engleză

Legare

Carte - Carte broșată

Publicat

2008

Pagini

EAN

9783836475808

ISBN

3836475804

Enbook ID

06938784

Editura

VDM Verlag Dr. Mueller E.K.

Greutate

109

Dimensiuni

152 x 229 x 4

Descriere completă

Comparative studies of bacterial genomes generate massive amounts of information. In order to support a systematic and efficient approach to genomic analyses, a database driven system with visualization capacity was developed. The GenComp software was applied to studies of intracellular bacteria. ORFs were extracted and grouped into families. Based on gene order synteny, orthologous clusters of core genes and variable spacer ORFs were identified and extracted for alignments and further analysis.§GenComp was applied to six Chlamydia trachomatis strains to identify the most rapidly evolving genes. Five genes were chosen for genotyping, and close to a 3-fold higher discrimination capacity was achieved than that of serotyping.§A massive comparative analysis were performed on the variable gene set in the Rickettsiaceae, which includes R. prowazekii and O. tsutsugamushi, the agents of epidemic and scrub typhus. The analysis indicates that up to 70% of the extensively degraded and variably present genes represent mobile genetic elements and genes putatively acquired by horizontal gene transfer. This explains the paradox of the high pseudogene load in the small Rickettsia genomes.

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Methods and Applications in Comparative Bacterial Genomics - Studying Microevolution in Action

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