Metal Complex-DNA Interactions

Name: Metal Complex-DNA Interactions
Brand: John Wiley and Sons Ltd
SKU: 9781405176293
Price: 948.06 RON
Availability: InStock

Autor: Nick Hadjiliadis, Einar Sletten

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Legare: Copertă tare

Editura: John Wiley and Sons Ltd

Disponibilitate: În depozitul extern

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948.06 lei

Metal ions and metal complexes have long been recognized as critically important components of nucle...

Informații despre carte

Autor

Nick Hadjiliadis, Einar Sletten

Limbă

engleză

Legare

Carte - Copertă tare

Publicat

2009

Pagini

544

EAN

9781405176293

ISBN

1405176296

Enbook ID

02590723

Editura

John Wiley and Sons Ltd

Greutate

1076

Dimensiuni

172 x 248 x 37

Descriere completă

Metal ions and metal complexes have long been recognized as critically important components of nucleic acid chemistry, both in regulation of gene expression and as promising therapeutic agents. Understanding how metal complexes interact with DNA has become an active research area at the interface between chemistry, molecular biology and medicine.§Metal Complex - DNA Interactions provides a comprehensive overview of this increasingly diverse field, presenting recent developments and the latest research with particular emphasis on metal-based drugs and metal ion toxicity. The text is divided into four parts:§Basic Structural and Kinetic Aspects: includes chapters on sequence-selective metal binding to DNA and thermodynamic models.§Medical Applications: focuses on anticancer platinum drugs, including discussions on DNA repair in antitumor effects of platinum drugs and photo-dynamic therapy.§DNA-Recognition - Nucleases and Sensor: describes probes for DNA recognition, artificial restriction agents, metallo-DNAzymes for metal sensing applications and metal ion dependent catalysis in nucleic acid enzymes.§Toxicological Aspects: deals with structural studies of mercury-DNA interactions, chromium-induced DNA damage and repair, and the effect of arsenic and nickel on DNA integrity.§This book will be a valuable resource for academic researchers and professionals from a range of pharmaceutical and chemical industries, particularly those involved in the development of new and less toxic anticancer metallo-drugs, and in the field of environmental and toxicological chemistry.

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