Melanotransferrin

Name: Melanotransferrin
Brand: VDM Verlag
SKU: 9783639140835
Price: 406.32 RON
Availability: InStock

Examination of the functional role of melanoma tumour antigen p97

Autor: Louise Dunn

Limbă:

Legare: Carte broșată

Editura: VDM Verlag

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Melanotransferrin (melanoma tumour antigen p97) is an§iron-§binding transferrin homologue expressed...

Informații despre carte

Autor

Louise Dunn

Limbă

engleză

Legare

Carte - Carte broșată

Publicat

2009

Pagini

236

EAN

9783639140835

ISBN

3639140834

Enbook ID

06822717

Editura

VDM Verlag

Greutate

349

Dimensiuni

152 x 229 x 14

Descriere completă

Melanotransferrin (melanoma tumour antigen p97) is an§iron-§binding transferrin homologue expressed at high§levels on §melanoma tumours and at lower levels on normal§tissues. Unlike its §relatives, transferrin and lactoferrin,§melanotransferrin is §membrane-bound. These properties suggest that§melanotransferrin §may assist melanoma and other tumour cell types with§their increased requirement for iron. To address this§hypothesis we §utilised models including: (i) the melanotransferrin§knockout mouse, and (ii) systematic down-regulation of §melanotransferrin in melanoma cells using siRNA.§Rigorous §phenotypic§characterisation of this knockout mouse demonstrated no §differences in iron metabolism, behaviour or other§physiological parameters compared to wild-type§controls. In §melanoma cells, melanotransferrin was found to§facilitate §proliferation and §migration, and also to enhance tumourigenesis in nude§mice. §Moreover, whole genome array analysis of these models§in addition §to cell models of melanotransferrin over-expression§indicated §differences in genes associated with growth.

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Melanotransferrin

Examination of the functional role of melanoma tumour antigen p97

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Descriere completă

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