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This fully revised 2e provides the only unified synthesis of available information concerning the mechanisms of higher-order memory formation. It spans the range from learning theory, to human and animal behavioral learning models, to cellular physiology and biochemistry. It is unique in its incorporation of chapters on memory disorders, tying in these clinically important syndromes with the basic science of synaptic plasticity and memory mechanisms. It also covers cutting-edge approaches such as the use of genetically engineered animals in studies of memory and memory diseases. Written in an engaging and easily readable style and extensively illustrated with many new, full-color figures to help explain key concepts, this book demystifies the complexities of memory and deepens the reader's understanding. * Five new chapters cover human learning and memory, the molecular and cellular basis of associative learning, Aplysia non-associative learning, the NMDA receptor, and experimental design. * Provides the latest research information on how disorders of molecular events in memory impact major neurological diseases, and how new treatments can thus be approached * Each chapter includes suggested readings for journal clubs, more introductory material for students, extensive cross-referencing to detailed, current reviews in Learning and Memory: A Comprehensive Reference (Academic Press, 2008). * A companion website provides figures in PowerPoint format plus additional, detailed further reading references * Extensively illustrated throughout with many new, full color figures to help explain key concepts * This edition includes new information about epigenetic mechanisms in memory function, glutamate receptor trafficking, invertebrate associative learning, working memory and the prefrontal cortex, motor learning, protein synthesis in memory and learning disabilities. * Furthermore, it covers new treatments of gene regulation in memory, place cells and grid cells, human neuroimaging, human motor learning and associative conditioning, Alzheimer's disease and learning disabilities.
