Malaria Immunopathology

Name: Malaria Immunopathology
Brand: VDM Verlag
SKU: 9783639136333
Price: 349.71 RON
Availability: InStock

Signaling and Cellular Mechanisms Involved in Hemozoin-inducible Proinflammatory Events

Autor: Maritza Jaramillo

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Editura: VDM Verlag

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Plasmodium is the causative agent of malaria, the §most deadly parasitic infection worldwide. §Patho...

Informații despre carte

Autor

Maritza Jaramillo

Limbă

engleză

Legare

Carte - Carte broșată

Publicat

2009

Pagini

172

EAN

9783639136333

ISBN

3639136330

Enbook ID

06822311

Editura

VDM Verlag

Greutate

259

Dimensiuni

152 x 229 x 10

Descriere completă

Plasmodium is the causative agent of malaria, the §most deadly parasitic infection worldwide. §Pathogenesis of the disease involves an exacerbated §immunological response; however, the role of §parasite components remains largely unexplored. The §current study was designed to assess the §contribution of hemozoin (HZ), a metabolic product §of Plasmodium, to the inflammatory events §associated to malaria. HZ was found to induce §various macrophage functions (e.g. chemokine and §nitric oxide production) through specific signaling §pathways. Importantly, the proinflammatory activity §of HZ was demonstrated in vivo (e.g. leukocytosis,§chemokine and cytokine release) using a murine §model. These findings support the idea that HZ §participates in inflammatory mediator overproduction §during malaria and therefore, it could be a key §component in the development of the disease. HZ §might emerge as an attractive target to design new §therapeutic approaches against malaria to prevent §millions of deaths. This book should be especially §useful to graduate students and researchers §interested in understanding the molecular and §cellular basis of malaria pathogenesis.

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Malaria Immunopathology

Signaling and Cellular Mechanisms Involved in Hemozoin-inducible Proinflammatory Events

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