Macromolecular Crystallography

conventional and high-throughput methods

Autor: Mark Sanderson, Jane V. Skelly

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Editura: Oxford University Press

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Macromolecular Crystallography is the study of macromolecules (proteins and nucleic acids) using X-r...

Informații despre carte

Autor

Mark Sanderson, Jane V. Skelly

Limbă

engleză

Legare

Carte - Copertă tare

Publicat

2007

Pagini

292

EAN

9780198520979

ISBN

0198520972

Enbook ID

04866083

Editura

Oxford University Press

Greutate

808

Dimensiuni

194 x 253 x 20

Descriere completă

Macromolecular Crystallography is the study of macromolecules (proteins and nucleic acids) using X-ray crystallographic techniques in order to determine their molecular structure. The knowledge of accurate molecular structures is a pre-requisite for rational drug design, and for structure-based function studies to aid the development of effective therapeutic agents and drugs. The successful determination of the complete genome (genetic sequence) of several species (including humans) has recently directed scientific attention towards identifying the structure and function of the complete complement of proteins that make up that species; a new and rapidly growing field of study called 'structural genomics'. There are now several important and well-funded global initiatives in operation to identify all of the proteins of key model species. One of the main requirements for these initiatives is a high-throughput crystallization facility to speed-up the protein identification process. The extent to which these technologies have advanced, calls for an updated review of current crystallographic theory and practice. This practical reference book features the latest conventional and high-throughput methods, and includes contributions from a team of internationally recognized leaders and experts. It will be of relevance and use to graduate students, research scientists and professionals currently working in the field of conventional and high-throughput macromolecular crystallography.

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Macromolecular Crystallography

conventional and high-throughput methods

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