Ligand-Receptor Energetics - A Guide for the Perplexed

Autor: Irving M. Klotz

Limbă:

Legare: Carte broșată

Editura: John Wiley & Sons Inc

Disponibilitate: În depozitul extern

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A foundation for quantitative perspectives and a framework for interpreting experimental observation...

Informații despre carte

Autor

Irving M. Klotz

Limbă

engleză

Legare

Carte - Carte broșată

Publicat

1997

Pagini

192

EAN

9780471176268

ISBN

0471176265

Enbook ID

04888153

Editura

John Wiley & Sons Inc

Greutate

294

Dimensiuni

156 x 228 x 12

Descriere completă

A foundation for quantitative perspectives and a framework for interpreting experimental observations. Researchers in the life sciences who are unaware of the origins of the fundamental concepts and theoretical constructs in ligand-receptor energetics may fail to recognize the hidden assumptions and premises in their interpretations of observed phenomena. This book offers a detailed exposition of these fundamentals and of the treatment of multiple equilibria in successive steps of the binding of ligands to receptors. It also describes the calculations and meanings of energetic quantities for ligand-receptor complexes. Ligand-Receptor Energetics is the only book on this topic that is both accessible to beginners and extremely useful for experienced investigators. It features numerous specific examples; tables of literature results; extensive, up-to-date thermodynamic data; graphical representations of ligand bonding concepts; and four helpful appendices. Topics covered include: Affinities -from site, stoichiometric, and ghost-site perspectives Facts and fantasies from graphical analyses Numerical evaluation of stoichiometric binding constants Affinity profiles Thermodynamic perspectives Forces of interaction Molecular scenarios. This valuable supplementary text for students in all areas of the basic life sciences is also an excellent professional reference for researchers in biochemistry, molecular biology, physiology, biophysics, microbiology, neurobiology, immunology, pharmacology, endocrinology, and toxicology.

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Ligand-Receptor Energetics - A Guide for the Perplexed

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