Leishmanicidal compounds

Name: Leishmanicidal compounds
Brand: LAP Lambert Academic Publishing
SKU: 9783659679308
Price: 264.03 RON
Availability: InStock

against L. tropica and L. mexicana

Autor: Doaa Abouelezz

Limbă:

Legare: Carte broșată

Editura: LAP Lambert Academic Publishing

Disponibilitate: În depozitul extern

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Leishmania parasites are responsible for a series of human diseases known as leishmaniasis which are...

Informații despre carte

Autor

Doaa Abouelezz

Limbă

engleză

Legare

Carte - Carte broșată

Publicat

2015

Pagini

EAN

9783659679308

Enbook ID

09357213

Editura

LAP Lambert Academic Publishing

Greutate

153

Dimensiuni

150 x 220 x 6

Descriere completă

Leishmania parasites are responsible for a series of human diseases known as leishmaniasis which are classified by the WHO as a major tropical disease. Current chemotherapy available for treatment is expensive and highly toxic and suffers from growing resistance in endemic areas. Reporter gene expression has now emerged as a new promising tool facilitating antileishmanial drug screening in vitro. In this project two chemical compounds RAPTA EA and RAPTA EAIMI and a plant extract PL-1 were screened for their antileishmanial activity against two Leishmania species; L. tropica and L. mexicana. Amphotericin B was used as a positive control to ensure the reliability of the drug assay and to act as reference for antileishmanial activity. Parasites constitutionally expressing GFP fluorescent protein were used for drug screening. The infection was quantified by the measurement of fluorescence intensity using flow cytometer. PL-1 was more effective than either RAPTA EA or RAPTA EAIMI in decreasing the percentage of infected THP-1 cells with either parasite, as it showed a lower IC50 value and it was not associated with toxicity to the THP-1 untreated cells ( 50 µg/ml).

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Leishmanicidal compounds

against L. tropica and L. mexicana

Informații despre carte

Descriere completă

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