Killer Lymphocytes

Name: Killer Lymphocytes
Brand: Springer-Verlag New York Inc.
SKU: 9781402032691
Price: 895.27 RON
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Autor: Gideon Berke, William R. Clark

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Legare: Copertă tare

Editura: Springer-Verlag New York Inc.

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We have known about the existence of killer lymphocytes since 1960, when they were discovered in con...

Informații despre carte

Autor

Gideon Berke, William R. Clark

Limbă

engleză

Legare

Carte - Copertă tare

Publicat

2005

Pagini

361

EAN

9781402032691

ISBN

1402032692

Enbook ID

01416080

Editura

Springer-Verlag New York Inc.

Greutate

1540

Dimensiuni

170 x 244 x 22

Descriere completă

We have known about the existence of killer lymphocytes since 1960, when they were discovered in connection with transplant rejection in vivo. Since then we have uncovered at least five subsets of lymphocytes that can kill other cells in vitro, establishing the study of cell-mediated cytotoxicity (CMC) as a major field of immunological inquiry. Berke and Clark summarize the extensive literature based on the study of CMC in vitro. Several important questions about killer cells have now been answered, for example, how they go about destroying other cells. Research ultimately revealed at least three lytic mechanisms available to killer lymphocytes. But do killer cells actually use these mechanisms in vivo? The possible involvement of CMC in transplant rejection, control of intracellular parasites, cancer, autoimmunity, and immune homeostatic regulation is analyzed in detail, yielding some surprising findings, and outlining important questions that remain unanswered.This extensively documented, comprehensive survey of cell-mediated cytotoxicity traces the history of killer lymphocytes from 1960 to the present, providing a definitive resource for specialists and non-specialists alike.

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