Ion Channels

Name: Ion Channels
Brand: Humana Press Inc.
SKU: 9781617376528
Price: 827.7 RON
Availability: InStock

Methods and Protocols

Autor: James D. Stockand, Mark S. Shapiro

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Legare: Carte broșată

Editura: Humana Press Inc.

Disponibilitate: În depozitul extern

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It is now clear that ion channels play essential roles in cell biology and physiology and that their...

Informații despre carte

Autor

James D. Stockand, Mark S. Shapiro

Limbă

engleză

Legare

Carte - Carte broșată

Publicat

2010

Pagini

216

EAN

9781617376528

ISBN

1617376523

Enbook ID

01432240

Editura

Humana Press Inc.

Greutate

334

Dimensiuni

152 x 229 x 13

Descriere completă

It is now clear that ion channels play essential roles in cell biology and physiology and that their dysfunction is the root cause of many human diseases. In Ion Channels: Methods and Protocols, internationally recognized biomedical scientists describe recent technological breakthroughs and demonstrate their use in successful experimental designs. The diverse applications range from the study of allosteric regulation of ion channel activity using a classic mutagenesis approach, to the study of channel subunit stoichiometry using a novel biophysical approach based on fluorescence resonance energy transfer. Highlights include methods for heterologous expression of ion channels in cells, for determining channel structure-function, for studying channel regulation and physiological function, and for genetic screening and investigating channelopathies. The protocols follow the successful Methods in Molecular Biology series format, each offering step-by-step laboratory instructions, an introduction outlining the principles behind the technique, lists of the necessary equipment and reagents, and tips on troubleshooting and avoiding known pitfalls.§Comprehensive and highly practical, Ion Channels: Methods and Protocols offer both novice and experienced researchers a versatile collection of proven techniques for illuminating the structure, function, and regulation of ion channel proteins and finding suitable drug targets when they cause disease.The diverse applications in this volume range from the study of allosteric regulation of ion channel activity using a classic mutagenesis approach, to the study of channel subunit stoichiometry using a novel biophysical approach based on fluorescence resonance energy transfer. Highlights include methods for heterologous expression of ion channels in cells, for determining channel structure-function, and for studying channel regulation.

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Ion Channels

Methods and Protocols

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