Immunologic Defects in Laboratory Animals 1

Name: Immunologic Defects in Laboratory Animals 1
Brand: Springer-Verlag New York Inc.
SKU: 9781475703276
Price: 551.47 RON
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Autor: M. Eric Gershwin, Bruce Merchant

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Editura: Springer-Verlag New York Inc.

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Tiselius demonstrated that the immunologically active components of immune sera migrated electrophor...

Informații despre carte

Autor

M. Eric Gershwin, Bruce Merchant

Limbă

engleză

Legare

Carte - Carte broșată

Publicat

2012

Pagini

380

EAN

9781475703276

ISBN

1475703279

Enbook ID

06797786

Editura

Springer-Verlag New York Inc.

Greutate

728

Dimensiuni

178 x 254 x 21

Descriere completă

Tiselius demonstrated that the immunologically active components of immune sera migrated electrophoretically in the gamma globulin region. His findings illuminated the classic observations of Jenner regarding development of resistance to infection, and those of von Pirquet, Pasteur, and Arthus regarding the transfer and specificity of resistance. Conceptual integration of these observations provided the impetus for the present modern era of immunology. Subsequent to Tiselius's work, multiple, rapid advances have occurred in the study of congenital and acquired immune deficiency states in mice, chickens, and humans. These studies have readily demonstrated that the immunologic ability of an organ ism to protect itself from environmental influences is a prerequisite for survival. Indeed, this necessity for protection from microenvironmental influences has promoted the evolu tionary development of immunologic diversification, namely, host dependence upon a sophisticated, multifaceted network of cells and effector mechanisms responsible for the clearance and neutralization of toxins and potentially harmful pathogens. The obligate dependence of animals upon the functional integrity of their immunologic systems is illus trated by the ready invasion of ubiquitous organisms when the host is in a state of immune defense derangement. Nevertheless, derangements in immune function can range from par tial to complete and can be compatible with survival. The consequences of such derange ments run the gamut from subclinical disease to inevitable mortality.

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Immunologic Defects in Laboratory Animals 1

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