Histochemical and Immunohistochemical Techniques

Name: Histochemical and Immunohistochemical Techniques
Brand: Springer
SKU: 9789401053709
Price: 275.77 RON
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Applications to pharmacology and toxicology

Autor: Peter H. Bach, J.R.J. Baker

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Editura: Springer

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Toxicological and pharmacological effects arise when chemicals interact with biophysiological functi...

Informații despre carte

Autor

Peter H. Bach, J.R.J. Baker

Limbă

engleză

Legare

Carte - Carte broșată

Publicat

2012

Pagini

289

EAN

9789401053709

ISBN

9401053707

Enbook ID

02184620

Editura

Springer

Greutate

447

Dimensiuni

152 x 229 x 17

Descriere completă

Toxicological and pharmacological effects arise when chemicals interact with biophysiological functions in discrete cell types. There is a continuing need to screen novel compounds for their potential therapeutic effects, and once these have been "discovered" to understand their molecular actions, as the basis of using such compounds safely and for rational drug design. Pharmacology now uses all of the sophisticated molecular research techniques that are available for the development of safer and more efficacious drugs. Histochemistry has been usefully applied to developing new drugs (and assessing chemical safley) and is potentially cost effective. The need to test novel substances for their potential adverse effects has raised many questions. Toxicological pathology has moved away from the cataloging of lesions towards understanding the basis of the events that underly cell injury, especially for those secondary consequences of chemical injury that lead to malignancy and chronic disease. The focal nature of toxicologic lesions de mands the use of microtechniques to provide data to help understand these questions. Histochemistry is under-utilized, but offers one of the key ap proaches necessary to address the problem of understanding interactions between a cell population and a chemical, the modulation of cellular biochem istryor the presence of a lesion in a test animal can be rationalised in terms of species differences that have no relevance to man as opposed to those that are of clinical significance or represent a warning of dire consequences to man.

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Histochemical and Immunohistochemical Techniques

Applications to pharmacology and toxicology

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Descriere completă

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