Gene Engineering in Endocrinology

Name: Gene Engineering in Endocrinology
Brand: Humana Press Inc.
SKU: 9781617371479
Price: 1306.45 RON
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Autor: Margaret A. Shupnik

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Editura: Humana Press Inc.

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During the past five to ten years, a variety of tools has been developed in the disciplines of both...

Informații despre carte

Autor

Margaret A. Shupnik

Limbă

engleză

Legare

Carte - Carte broșată

Publicat

2010

Pagini

428

EAN

9781617371479

ISBN

1617371475

Enbook ID

06798261

Editura

Humana Press Inc.

Greutate

928

Dimensiuni

178 x 254 x 25

Descriere completă

During the past five to ten years, a variety of tools has been developed in the disciplines of both gene engineering, and molecular and structural biology. Some of these advances have permitted scientists not only to identify and characterize genes, but also to target these genes by disruption, thus eliminating their function in living animals, and to det- mine the biological responses to altered gene products. This has particular significance in endocrine systems, in which feedback mechanisms between the hypothalamus, pi- itary, and end organs are critical in normal physiology. Interpretation of the physiological significance, or the site of action of specific molecules in this context, has been difficult prior to transgenic technology. Major advances have occurred specifically in the areas of growth and development, and of reproduction. Coupled with analysis of naturally occurring mutations in humans, the use of transgenic animals and in vitro systems has recently allowed endocrinologists to understand the importance of specific thyroid hormone receptor isoforms in vivo, the molecular basis for generalized resistance to thyroid hormones via mutations in the nuclear receptor, and mechanisms for suppressing gene transcription. Previously designated orphan rec- tors, such as steroidogenic factor-1, were demonstrated to have critical roles in dev- opment and reproduction. Other nuclear receptors including those for thyroid hormone, estrogens, androgens, and progesterone were shown to bind to coactivator and co- pressor proteins that modified their transcriptional activity, and contributed to the ce- specific effects of the hormones.

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