Gemcitabine

Name: Gemcitabine
Brand: Nova Science Publishers Inc
SKU: 9781633210110
Price: 780.88 RON
Availability: InStock

Pharmacology, Clinical Uses & Potential Side Effects

Autor: Howard L Reese

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Editura: Nova Science Publishers Inc

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780.88 lei

Gemcitabine was synthesised in the 1980s at Lilly Research Laboratories (Eli Lilly and Co., Indianap...

Informații despre carte

Autor

Howard L Reese

Limbă

engleză

Legare

Carte - Carte broșată

Publicat

2014

Pagini

EAN

9781633210110

ISBN

9781633210110

Enbook ID

06430807

Editura

Nova Science Publishers Inc

Greutate

198

Dimensiuni

144 x 224 x 8

Descriere completă

Gemcitabine was synthesised in the 1980s at Lilly Research Laboratories (Eli Lilly and Co., Indianapolis, IN). It was initially developed as an antiviral agent, but it had an extremely narrow therapeutic index due to its cytotoxicity against the parental cell lines. As it presented wide activity against various solid tumors it was then evaluated as an anticancer drug. This pyrimidine antimetabolite was firstly approved in 1996 by the Food and Drug Administration (FDA) for the treatment of pancreatic cancer. It is currently used for the treatment of many other malignancies such as lung cancer, breast cancer, lymphoma, bladder cancer, mesothelioma and ovarian cancer. This book discusses the molecular pharmacology, and the pharmacogenetics of gemcitabine. It also discusses the antineoplastic mechanism of gemcitabine on tumour cells; the systemic adverse effects; and provides detail on the clinical uses gemcitabine has on breast cancer.

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Gemcitabine

Pharmacology, Clinical Uses & Potential Side Effects

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