From Bench to Market

The Evolution of Chemical Synthesis

Autor: Walter Cabri, Romano Di Fabio

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Legare: Carte broșată

Editura: Oxford University Press

Disponibilitate: În depozitul extern

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Who wins the race to turn molecules into medicines? How much does it cost? What factors influence th...

Informații despre carte

Autor

Walter Cabri, Romano Di Fabio

Limbă

engleză

Legare

Carte - Carte broșată

Publicat

2000

Pagini

284

EAN

9780198503835

ISBN

0198503830

Enbook ID

04526831

Editura

Oxford University Press

Greutate

534

Dimensiuni

189 x 246 x 16

Descriere completă

Who wins the race to turn molecules into medicines? How much does it cost? What factors influence the choice of synthetic routes and reaction mechanisms? How can pharmaceutical companies protect their discoveries? In From Bench to Market, Walter Cabri and Romano Di Fabio chart the process of industrial chemical synthesis, from the first discovery of a molecule, or 'new chemical entity', to its entry in the marketplace as a drug. They discuss all aspects related to the process research for bulk production, including comparison between different synthetic routes, key methodologies and reaction mechanisms, costs, patent competition, and crystalline forms. The authors use the real chemical history of the development of drugs from several therapeutic areas as detailed case studies, each chosen to illustrate a range of issues and methodologies in industrial chemistry. Several chapters cover the development of the various sz-lactam antibiotics; two chapters describe the discovery and synthesis of the anticancer drugs Idarubicin and Paclitaxal; in another chapter, the synthesis of the anti-viral drug Acyclovir and the 'patent war' that resulted are explored. Between them, the authors represent considerable first-hand experience in pharmaceutical research and development. The technical, practical, and strategic information they have amassed make this essential reading for graduate and undergraduate chemists intending to work in the pharmaceutical industry, as well as for industrial chemists themselves. Lecturers teaching courses in medicinal and organic chemistry will also find it useful.

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From Bench to Market

The Evolution of Chemical Synthesis

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