Carte Filaggrin Jacob P. Thyssen

Filaggrin

Basic Science, Epidemiology, Clinical Aspects and Management

Limbă: engleză
Legare: Carte broșată
Disponibilitate: La editor doar la comandă
Expediem în 17-27 zile
525.48 lei
Filaggrin gene mutations are common in Europeans and their descendants, as well as in Asians, reachi...

Informații despre carte

Limbă
engleză
Legare
Carte - Carte broșată
Publicat
2016
Pagini
373
EAN
9783662511176
ISBN
3662511177
Enbook ID
13788448
Greutate
8222
Dimensiuni
178 x 254 x 20

Descriere completă

Filaggrin gene mutations are common in Europeans and their descendants, as well as in Asians, reaching a prevalence of up to 10%. Filaggrin proteins are crucial for skin homeostasis as their metabolites maintain skin hydration, keep the skin pH low, and provide protection against solar radiation. FLG mutation carriers suffer from dry and scaly skin and have an increased transfer of allergens and chemicals across the epidermis. Moreover, they have 10% higher serum vitamin D levels, potentially affecting the propensity to develop other diseases. FLG loss-of-function mutations represent the strongest risk factor hitherto discovered for atopic dermatitis and are major predisposing factors for related asthma and hay fever. This textbook provides comprehensive and detailed coverage of the effects of FLG mutations in health and disease (cutaneous and non-cutaneous) and also discusses the basic science, epidemiology, management, and future research areas.

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