Dose Painting IMRT Using Biological Parameters

Name: Dose Painting IMRT Using Biological Parameters
Brand: Scholars' Press
SKU: 9783639702729
Price: 248.74 RON
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Autor: Yusung Kim, Wolfgang A. Tomé

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Editura: Scholars' Press

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248.74 lei

Currently, there is great interest in incorporating biological information into intensity-modulated...

Informații despre carte

Autor

Yusung Kim, Wolfgang A. Tomé

Limbă

engleză

Legare

Carte - Carte broșată

Publicat

2014

Pagini

164

EAN

9783639702729

ISBN

3639702727

Enbook ID

07172438

Editura

Scholars' Press

Greutate

249

Dimensiuni

152 x 229 x 10

Descriere completă

Currently, there is great interest in incorporating biological information into intensity-modulated radiotherapy (IMRT) treatment planning with the aim of selectively boosting high-risk tumor subvolumes a concept that has also been called dose painting . However, conventional IMRT optimization utilizes dose-volume based objective functions, which have inherent limitations such as pursuing homogeneous dose distributions and assuming linear-dose-response curves. In this book we present a dose painting IMRT optimization-framework in which nonlinear biological objective functions are utilized. Prostate cancer has been used as a model system to explore its feasibility. The impact of functional imaging accuracy such as sensitivity and specificity on dose painting IMRT is subsequently presented. A comparison study between dose painting IMRT strategies and uniform-boosting IMRT strategies yielding the same EUD to the overall PTV is also presented. A novel dose painting IMRT strategy using biological parameters is proposed and promises increased expected local control for locoregionally advanced tumors with equivalent or better normal tissue sparing.

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