DNA Systems Under Internal and External Forcing

Name: DNA Systems Under Internal and External Forcing
Brand: Springer Nature Switzerland AG
SKU: 9783030254155
Price: 615.07 RON
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Autor: Megan Clare Engel

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Legare: Carte broșată

Editura: Springer Nature Switzerland AG

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The interactions of DNA with force are central to manifold fields of inquiry, including the de novo...

Informații despre carte

Autor

Megan Clare Engel

Limbă

engleză

Legare

Carte - Carte broșată

Publicat

2020

Pagini

144

EAN

9783030254155

ISBN

3030254151

Enbook ID

33256264

Editura

Springer Nature Switzerland AG

Greutate

256

Dimensiuni

155 x 235 x 9

Descriere completă

The interactions of DNA with force are central to manifold fields of inquiry, including the de novo design of DNA nanostructures, the use of DNA to probe the principles of biological self-assembly, and the operation of cellular nanomachines. This work presents a survey of three distinct ways coarse-grained simulations can help characterize these interactions. A non-equilibrium energy landscape reconstruction technique is validated for use with the oxDNA model and a practical framework to guide future applications is established. A novel method for calculating entropic forces in DNA molecules is outlined and contrasted with existing, flawed approaches. Finally, a joint experimental-simulation study of large DNA origami nanostructures under force sheds light on design principles and, through vivid illustrations, their unfolding process. This text provides an accessible and exciting launching point for any student interested in the computational study of DNA mechanics and force interactions.

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DNA Systems Under Internal and External Forcing

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