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Decoding the Antibody Repertoire

Name: Decoding the Antibody Repertoire
Brand: Springer International Publishing AG
SKU: 9783319585178
Price: 580.45 RON
Availability: InStock

Autor: Brandon DeKosky

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Legare: Copertă tare

Editura: Springer International Publishing AG

Disponibilitate: În depozitul extern în cantități mici

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580.45 lei

This thesis outlines the development of the very first technology for high-throughput analysis of pa...

Informații despre carte

Autor

Brandon DeKosky

Limbă

engleză

Legare

Carte - Copertă tare

Publicat

2017

Pagini

EAN

9783319585178

ISBN

3319585177

Enbook ID

16190177

Editura

Springer International Publishing AG

Greutate

344

Dimensiuni

155 x 235 x 13

Descriere completă

This thesis outlines the development of the very first technology for high-throughput analysis of paired heavy and light-chain antibody sequences, opening an entirely new window for antibody discovery and the investigation of adaptive immune responses to vaccines and diseases.Previous methods for high-throughput immune repertoire sequencing have been unable to provide information on the identity of immune receptor pairs encoded by individual B or T lymphocytes. The author directly addresses these limitations by designing two new technologies for sequencing multiple mRNA transcripts from up to 10 million isolated, single cells. The techniques developed in this work have enabled comprehensive interrogation of human B-cell repertoires and have been applied for rapid discovery of new human antibodies, to gain new insights into the development of human antibody repertoires, and for analysis of human immune responses to vaccination and disease.

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Decoding the Antibody Repertoire

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