Cystic Fibrosis

Name: Cystic Fibrosis
Brand: LAP LAMBERT Academic Publishing
SKU: 9786209166716
Price: 292.51 RON
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Autor: Zahia Boucherit-Otmani

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Editura: LAP LAMBERT Academic Publishing

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292.51 lei

Cystic fibrosis (CF) is a lethal genetic disorder mainly affecting Caucasians, caused by mutations i...

Informații despre carte

Autor

Zahia Boucherit-Otmani

Limbă

engleză

Legare

Carte - Carte broșată

Publicat

2025

Pagini

100

EAN

9786209166716

ISBN

6209166717

Enbook ID

50094364

Editura

LAP LAMBERT Academic Publishing

Greutate

167

Dimensiuni

150 x 220 x 6

Descriere completă

Cystic fibrosis (CF) is a lethal genetic disorder mainly affecting Caucasians, caused by mutations in the CFTR gene encoding a chloride ion channel. The most common F508 mutation alters CFTR folding and prevents its expression on epithelial cell surfaces, disrupting ion and water transport and leading to thick mucus, a hallmark of CF lung disease. Treatments have advanced, with antibiotics managing chronic infections and CFTR modulators (ivacaftor, tezacaftor, elexacaftor) improving protein function. Yet, many patients with rare mutations or drug resistance remain untreated. Emerging therapies now focus on gene therapy to correct or replace the defective CFTR gene and on cell therapy to regenerate functional epithelium from corrected stem cells. Combining these strategies offers a promising path toward personalized, long-term correction of the molecular cause of CF.

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Cystic Fibrosis

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