Computational Methods for Fragment Spectrum Interpretation

Name: Computational Methods for Fragment Spectrum Interpretation
Brand: VDM Verlag
SKU: 9783639228588
Price: 274.76 RON
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Computational Interpretation of Tandem MS Spectra Including Fragment Ions with Post-Translational Modifications

Autor: Jonathan Rameseder, Lennart Martens

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Editura: VDM Verlag

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274.76 lei

Post-translational modifications (PTMs) are of critical importance for a vast range of cellular proc...

Informații despre carte

Autor

Jonathan Rameseder, Lennart Martens

Limbă

engleză

Legare

Carte - Carte broșată

Publicat

2010

Pagini

EAN

9783639228588

ISBN

3639228588

Enbook ID

06830633

Editura

VDM Verlag

Greutate

Dimensiuni

152 x 229 x 10

Descriere completă

Post-translational modifications (PTMs) are of critical importance for a vast range of cellular processes such as growth control and signal transduction. Mass spectrometry (MS) can shed light on the characteristics of PTMs to gain insight into the mechanisms of numerous diseases including cancer. However, interpretation of tandem MS spectra including fragment ions with PTMs from high-throughput experiments is a complex challenge. The high number and diversity of known PTMs as well as suboptimal quality of spectra compromise the identification of PTMs in MS experiments. In this book, an efficient algorithm for the computational interpretation of tandem MS spectra including fragment ions with PTMs is described. Information on both precursor and fragment ion level is utilized and an arbitrary number of PTMs is considered. A robust statistical noise intensity model is developed to compensate for low spectrum quality. Finally, the algorithm is successfully applied on the fragment spectra in the PRIDE proteomics data repository to render it suitable for statistical machine learning investigations.

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Computational Methods for Fragment Spectrum Interpretation

Computational Interpretation of Tandem MS Spectra Including Fragment Ions with Post-Translational Modifications

Informații despre carte

Descriere completă

S-ar putea să te intereseze

Clienții care au cumpărat această carte au mai cumpărat și