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Carte Complement P. A. Miescher

Complement

Autor: P. A. Miescher, H. J. Müller-Eberhard
Limbă: engleză
Legare: Carte broșată
Editura: Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
Disponibilitate: În depozitul extern
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551.23 lei
Activation of the complement system gives rise to a number of molecular species which can interact w...

Informații despre carte

Autor
P. A. Miescher, H. J. Müller-Eberhard
Limbă
engleză
Legare
Carte - Carte broșată
Publicat
1985
Pagini
474
EAN
9783540150756
ISBN
9783540150756
Enbook ID
06620857
Editura
Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
Greutate
865
Dimensiuni
170 x 244 x 27

Descriere completă

Activation of the complement system gives rise to a number of molecular species which can interact with host-derived cells and regulate their function. This interaction is mediated through distinct cell surface complement receptors, and receptor engagement produces biologic responses which can either modulate host defense reactions or enhance inflammation. Although the first complement receptor was recognized more than 30 years ago [80J, detailed biochemical information concerning the receptors has only recently become available. Currently, eight distinct complement receptors are recognized. Five receptors (CRl, CR2, CR3, C3a receptor, and C3e receptor) react with various regions on C3 while the other receptors display specificity for Clq, C5a, or Factor H. This chapter focusses on the chemistry of the various ligands and receptors and discusses the biologic activities which arise as a result of receptor-ligand interaction. II. CIQ Receptor A. The Ligand Clq is the recognition molecule of the classical complement pathway [reviewed in 20, 130]. In serum, it is part of a calcium-dependent penta molecular complex containing one molecule ofClq and two molecules each of the pro enzymes Clr and CIs. During classical pathway activation, the macromolecular complex becomes associated with the activator through the Clq subcomponent. Bound Clq undergoes a conformational change and induces the proteolytic autoactivation of Clr which in turn effects the proteolytic activation of CIs. This process is controlled by the Cl inhibitor (ClINH) which binds irreversibly to activated Clr and CIs, and inhibits their enzymatic activities.

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